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Article Dans Une Revue Nature Communications Année : 2022

The mouse metallomic landscape of aging and metabolism

Jean-David Morel
  • Fonction : Auteur
Lucie Sauzéat
Ludger J. E. Goeminne
  • Fonction : Auteur
Pooja Jha
  • Fonction : Auteur
Evan Williams
  • Fonction : Auteur
Riekelt H. Houtkooper
  • Fonction : Auteur
Ruedi Aebersold
  • Fonction : Auteur
Johan Auwerx
  • Fonction : Auteur

Résumé

Organic elements make up 99% of an organism but without the remaining inorganic bioessential elements, termed the metallome, no life could be possible. The metallome is involved in all aspects of life, including charge balance and electrolytic activity, structure and conformation, signaling, acid-base buffering, electron and chemical group transfer, redox catalysis energy storage and biomineralization. Here, we report the evolution with age of the metallome and copper and zinc isotope compositions in five mouse organs. The aging metallome shows a conserved and reproducible fingerprint. By analyzing the metallome in tandem with the phenome, metabolome and proteome, we show networks of interactions that are organ-specific, age-dependent, isotopically-typified and that are associated with a wealth of clinical and molecular traits. We report that the copper isotope composition in liver is age-dependent, extending the existence of aging isotopic clocks beyond bulk organic elements. Furthermore, iron concentration and copper isotope composition relate to predictors of metabolic health, such as body fat percentage and maximum running capacity at the physiological level, and adipogenesis and OXPHOS at the biochemical level. Our results shed light on the metallome as an overlooked omic layer and open perspectives for potentially modulating cellular processes using careful and selective metallome manipulation.
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insu-03708910 , version 1 (29-06-2022)

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Jean-David Morel, Lucie Sauzéat, Ludger J. E. Goeminne, Pooja Jha, Evan Williams, et al.. The mouse metallomic landscape of aging and metabolism. Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28060-x⟩. ⟨insu-03708910⟩
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