*. Ilaria, Standard for Property Specification Language (PSL)

. Orcid-id,

J. Karges, Events, Loss Prevention Bulletin, vol.174, issue.1, pp.31-31, 2003.

F. Heinemann,

F. Maschietto, Giuliano, Federica Giuseppina, pp.0-0002, 2011.

M. Jakubaszek, ANNOUNCEMENTS, Acta Dermato-Venereologica, vol.79, issue.4, pp.336-336, 1999.

C. Subecz,

M. Dotou, ANNOUNCEMENTS, Acta Dermato-Venereologica, vol.79, issue.4, pp.336-336, 1999.

O. Blacque, , pp.0-0001

B. Goud, , pp.0-0003

E. Viñuelas and Z. , , pp.0-0003

B. Spingler, Spingler, F.J., pp.0-0003, 2011.

M. Ciofini and A. Lapucci, Compact scalable diode-pumped Nd:YAG ceramic slab laser, Applied Optics, vol.43, issue.33, p.6174, 2004.

G. Gasser, , pp.0-0002

D. E. Dolmans, D. Fukumura, and R. K. Jain, Photodynamic therapy for cancer, Nature Reviews Cancer, vol.3, issue.5, pp.380-387, 2003.

K. Plaetzer, B. Krammer, J. Berlanda, F. Berr, and T. Kiesslich, Photophysics and photochemistry of photodynamic therapy: fundamental aspects, Lasers in Medical Science, vol.24, issue.2, pp.259-268, 2008.

S. Bonnet, Why develop photoactivated chemotherapy?, Dalton Transactions, vol.47, issue.31, pp.10330-10343, 2018.

R. Bonnett, Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy, Chemical Society Reviews, vol.24, issue.1, p.19, 1995.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel et al., Photodynamic Therapy, JNCI Journal of the National Cancer Institute, vol.90, issue.12, pp.889-905, 1998.

B. W. Henderson and T. J. Dougherty, HOW DOES PHOTODYNAMIC THERAPY WORK?, Photochemistry and Photobiology, vol.55, issue.1, pp.145-157, 1992.

A. E. O?connor, W. M. Gallagher, and A. T. Byrne, Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy, Photochemistry and Photobiology, vol.85, issue.5, pp.1053-1074, 2009.

A. Naik, R. Rubbiani, G. Gasser, and B. Spingler, Visible-Light-Induced Annihilation of Tumor Cells with Platinum-Porphyrin Conjugates, Angewandte Chemie International Edition, vol.53, issue.27, pp.6938-6941, 2014.

F. Heinemann, J. Karges, and G. Gasser, Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy, Accounts of Chemical Research, vol.50, issue.11, pp.2727-2736, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01626728

J. Karges, U. Basu, O. Blacque, H. Chao, and G. Gasser, Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers, Angewandte Chemie International Edition, vol.58, issue.40, pp.14334-14340, 2019.

P. M. Antoni, A. Naik, I. Albert, R. Rubbiani, S. Gupta et al., (Metallo)porphyrins as Potent Phototoxic Anti-Cancer Agents after Irradiation with Red Light, Chemistry - A European Journal, vol.21, issue.3, pp.1179-1183, 2014.

P. Agostinis, K. Berg, K. A. Cengel, T. H. Foster, A. W. Girotti et al., Photodynamic therapy of cancer: An update, CA: A Cancer Journal for Clinicians, vol.61, issue.4, pp.250-281, 2011.

S. O. Girotti, S. M. Gollnick, M. R. Hahn, A. Hamblin, D. Juzeniene et al., Photodynamic therapy of cancer: an update, CA Cancer J. Clin, vol.61, pp.250-281, 2011.

S. Callaghan and M. O. Senge, The good, the bad, and the ugly ? controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy, Photochemical & Photobiological Sciences, vol.17, issue.11, pp.1490-1514, 2018.

L. Schneider, M. Larocca, W. Wu, V. Babu, R. Padrutt et al., Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy, Photochemical & Photobiological Sciences, vol.18, issue.11, pp.2792-2803, 2019.

C. Mari, V. Pierroz, S. Ferrari, and G. Gasser, Combination of Ru(ii) complexes and light: new frontiers in cancer therapy, Chemical Science, vol.6, issue.5, pp.2660-2686, 2015.

S. Monro, K. L. Colón, H. Yin, J. Roque, P. Konda et al., Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433, Chemical Reviews, vol.119, issue.2, pp.797-828, 2018.

L. Zeng, P. Gupta, Y. Chen, E. Wang, L. Ji et al., The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials, Chemical Society Reviews, vol.46, issue.19, pp.5771-5804, 2017.

L. K. Mckenzie, H. E. Bryant, and J. A. Weinstein, Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy, Coordination Chemistry Reviews, vol.379, pp.2-29, 2019.

A. Li, C. Turro, and J. J. Kodanko, Ru(II) Polypyridyl Complexes Derived from Tetradentate Ancillary Ligands for Effective Photocaging, Accounts of Chemical Research, vol.51, issue.6, pp.1415-1421, 2018.

J. Liu, C. Zhang, T. W. Rees, L. Ke, L. Ji et al., Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy, Coordination Chemistry Reviews, vol.363, pp.17-28, 2018.

F. E. Poynton, S. A. Bright, S. Blasco, D. C. Williams, J. M. Kelly et al., The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications, Chemical Society Reviews, vol.46, issue.24, pp.7706-7756, 2017.

M. Jakubaszek, J. Rossier, J. Karges, J. Delasoie, B. Goud et al., Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy, Helvetica Chimica Acta, vol.102, issue.7, p.1900104, 2019.

J. Shum, P. Leung, and K. Lo, Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications, Inorganic Chemistry, vol.58, issue.4, pp.2231-2247, 2019.

K. Qiu, Y. Chen, T. W. Rees, L. Ji, and H. Chao, Organelle-targeting metal complexes: From molecular design to bio-applications, Coordination Chemistry Reviews, vol.378, pp.66-86, 2019.

J. Karges, M. Jakubaszek, C. Mari, K. Zarschler, B. Goud et al., Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy, J. Am. Chem. Soc, vol.135, pp.17161-17175, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02273716

Y. Ellahioui, M. Patra, C. Mari, R. Kaabi, J. Karges et al., Mesoporous silica nanoparticles functionalised with a photoactive ruthenium(ii) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser, Dalton Transactions, vol.48, issue.18, pp.5940-5951, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02055800

B. S. Howerton, D. K. Heidary, and E. C. Glazer, Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents, Journal of the American Chemical Society, vol.134, issue.20, pp.8324-8327, 2012.

J. D. Knoll and C. Turro, Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy, Coordination Chemistry Reviews, vol.282-283, pp.110-126, 2015.

A. M. Palmer, B. Peña, R. B. Sears, O. Chen, M. El-ojaimi et al., Cytotoxicity of cyclometallated ruthenium complexes: the role of ligand exchange on the activity, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.371, issue.1995, p.20120135, 2013.

, A Phase 1 Study of Intravesical VAX014 for Instillation in Subjects With Non-Muscle Invasive Bladder Cancer, Case Medical Research, p.32, 2019.

J. Fong, K. Kasimova, Y. Arenas, P. Kaspler, S. Lazic et al., A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors, Photochemical & Photobiological Sciences, vol.14, issue.11, pp.2014-2023, 2015.

P. Kaspler, S. Lazic, S. Forward, Y. Arenas, A. Mandel et al., A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy, Photochemical & Photobiological Sciences, vol.15, issue.4, pp.481-495, 2016.

S. A. Mcfarland, A. Mandel, R. Dumoulin-white, and G. Gasser, Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?, Current Opinion in Chemical Biology, vol.56, pp.23-27, 2020.
URL : https://hal.archives-ouvertes.fr/hal-02373926

S. M. Cloonan, R. B. Elmes, M. Erby, S. A. Bright, F. E. Poynton et al., Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells, Journal of Medicinal Chemistry, vol.58, issue.11, pp.4494-4505, 2015.

J. Karges, O. Blacque, M. Jakubaszek, B. Goud, P. Goldner et al., Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes, Journal of Inorganic Biochemistry, vol.198, p.110752, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02160031

H. Yin, M. Stephenson, J. Gibson, E. Sampson, G. Shi et al., In VitroMultiwavelength PDT with3IL States: Teaching Old Molecules New Tricks, Inorganic Chemistry, vol.53, issue.9, pp.4548-4559, 2014.

E. Wachter, D. K. Heidary, B. S. Howerton, S. Parkin, and E. C. Glazer, Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window, Chemical Communications, vol.48, issue.77, p.9649, 2012.

L. Wang, H. Yin, M. A. Jabed, M. Hetu, C. Wang et al., ?-Expansive Heteroleptic Ruthenium(II) Complexes as Reverse Saturable Absorbers and Photosensitizers for Photodynamic Therapy, Inorganic Chemistry, vol.56, issue.6, pp.3245-3259, 2017.

K. Ogawa and Y. Kobuke, Recent Advances in Two-Photon Photodynamic Therapy, Anti-Cancer Agents in Medicinal Chemistry, vol.8, issue.3, pp.269-279, 2008.

B. C. Wilson, W. P. Jeeves, and D. M. Lowe, IN VIVO and POST MORTEM MEASUREMENTS OF THE ATTENUATION SPECTRA OF LIGHT IN MAMMALIAN TISSUES, Photochemistry and Photobiology, vol.42, issue.2, pp.153-162, 1985.

M. Eriksson, M. Leijon, C. Hiort, B. Norden, and A. Graeslund, Binding of .DELTA.- and .LAMBDA.-[Ru(phen)3]2+ to [d(CGCGATCGCG)]2 Studied by NMR, Biochemistry, vol.33, issue.17, pp.5031-5040, 1994.

. Graeslund, 2 evidenced by two-dimensional NMR, J. Am. Chem. Soc, vol.114, pp.4933-4934, 1992.

M. Dickerson, Y. Sun, B. Howerton, and E. C. Glazer, Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks, Inorganic Chemistry, vol.53, issue.19, pp.10370-10377, 2014.

H. Audi, D. F. Azar, F. Mahjoub, S. Farhat, Z. El-masri et al., Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge, Journal of Photochemistry and Photobiology A: Chemistry, vol.351, pp.59-68, 2018.

S. Mehanna, N. Mansour, H. Audi, K. Bodman-smith, M. A. Mroueh et al., Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(ii) polypyridyl complex, RSC Advances, vol.9, issue.30, pp.17254-17265, 2019.

N. Mansour, S. Mehanna, M. A. Mroueh, H. Audi, K. Bodman-smith et al., Photoactivatable RuIIComplex Bearing 2,9-Diphenyl-1,10-phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin-Resistant Cell Lines, European Journal of Inorganic Chemistry, vol.2018, issue.22, pp.2524-2532, 2018.

S. Finck, J. Issenhuth, S. Despax, C. Sirlin, M. Pfeffer et al.,

. Daniel, Structural and optical properties of new cyclometalated Ru(II) derived compounds, J. Organomet. Chem, vol.760, pp.248-259, 2014.

S. Campagna, F. Puntoriero, F. Nastasi, G. Bergamini, and V. Balzani, Photochemistry and Photophysics of Coordination Compounds: Ruthenium, Photochemistry and Photophysics of Coordination Compounds I, pp.117-214

J. Karges, F. Heinemann, F. Maschietto, M. Patra, O. Blacque et al., A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers, Bioorganic & Medicinal Chemistry, vol.27, issue.12, pp.2666-2675, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02125888

G. A. Crosby and W. H. Elfring, Excited states of mixed ligand chelates of ruthenium(II) and rhodium(III), The Journal of Physical Chemistry, vol.80, issue.20, pp.2206-2211, 1976.

W. E. Jones, R. A. Smith, M. T. Abramo, M. D. Williams, and J. Van-houten, Photochemistry of hetero-tris-chelated ruthenium(II) polypyridine complexes in dichloromethane, Inorganic Chemistry, vol.28, issue.12, pp.2281-2285, 1989.

O. Mazuryk, K. Magiera, B. Rys, F. Suzenet, C. Kieda et al., Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties, JBIC Journal of Biological Inorganic Chemistry, vol.19, issue.8, pp.1305-1316, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01179428

W. Huang and T. Ogawa, Spontaneous resolution of ? and ? enantiomeric pair of [Ru(phen)(bpy)2](PF6)2 (phen=1,10-phenanthroline, bpy=2,2?-bipyridine) by conglomerate crystallization, Polyhedron, vol.25, issue.6, pp.1379-1385, 2006.

M. J. Cook, A. P. Lewis, G. S. Mcauliffe, V. Skarda, A. J. Thomson et al., Luminescent metal complexes. Part 1. Tris-chelates of substituted 2,2?-bipyridyls with ruthenium (II) as dyes for luminescent solar collectors, J. Chem. Soc., Perkin Trans. 2, vol.1, issue.8, pp.1293-1301, 1984.

V. Balzani and A. Juris, Photochemistry and photophysics of Ru(II)?polypyridine complexes in the Bologna group. From early studies to recent developments, Coordination Chemistry Reviews, vol.211, issue.1, pp.97-115, 2001.

O. Maury, J. Guegan, T. Renouard, A. Hilton, P. Dupau et al., ChemInform Abstract: Design and Synthesis of 4,4?-?-Conjugated[2,2?]-bipyridines: A Versatile Class of Tunable Chromophores and Fluorophores., ChemInform, vol.33, issue.29, pp.no-no, 2010.

J. Karges, O. Blacque, P. Goldner, H. Chao, and G. Gasser, Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3 ]2+ Core, European Journal of Inorganic Chemistry, vol.2019, issue.32, pp.3704-3712, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02273765

J. Karges and G. Gasser, Synthesis, Characterisation and Biological Evaluation of ?-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy, Inorganica Chimica Acta, vol.499, p.119196, 2020.
URL : https://hal.archives-ouvertes.fr/hal-02311863

J. Karges, P. Goldner, and G. Gasser, Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes, Inorganics, vol.7, issue.1, p.4, 2019.
URL : https://hal.archives-ouvertes.fr/hal-01971696

A. A. Abdel-shafi, P. D. Beer, R. J. Mortimer, and F. Wilkinson, Photosensitized Generation of Singlet Oxygen from (Substituted Bipyridine)ruthenium(II) Complexes, Helvetica Chimica Acta, vol.84, issue.9, p.2784, 2001.

. Wilkinson, Photosensitized generation of singlet oxygen from (substituted bipyridine) ruthenium (II) complexes, Helv. Chim. Acta, vol.84, pp.2784-2795, 2001.

D. Garcìa-fresnadillo, Y. Georgiadou, G. Orellana, A. M. Braun, and E. Oliveros, Singlet-Oxygen (1?g) Production by Ruthenium(II) complexes containing polyazaheterocyclic ligands in methanol and in water, Helvetica Chimica Acta, vol.79, issue.4, pp.1222-1238, 1996.

M. Patra, T. Joshi, V. Pierroz, K. Ingram, M. Kaiser et al., DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity ofN-Heterocyclic-[Ru(?6-arene)Cl2] Drug Candidates, Chemistry - A European Journal, vol.19, issue.44, pp.14768-14772, 2013.

M. D. Hall, K. A. Telma, K. Chang, T. D. Lee, J. P. Madigan et al., Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes, Cancer Research, vol.74, issue.14, pp.3913-3922, 2014.

J. R. Madigan, I. S. Lloyd, J. D. Goldlust, M. M. Hoeschele, and . Gottesman, Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes, Cancer Res, vol.74, pp.3913-3922, 2014.

S. Keller, Y. C. Ong, Y. Lin, K. Cariou, and G. Gasser, A tutorial for the assessment of the stability of organometallic complexes in biological media, Journal of Organometallic Chemistry, vol.906, p.121059, 2020.
URL : https://hal.archives-ouvertes.fr/hal-02393969

S. J. Bruce, I. Tavazzi, V. R. Parisod, S. Rezzi, S. Kochhar et al., Investigation of Human Blood Plasma Sample Preparation for Performing Metabolomics Using Ultrahigh Performance Liquid Chromatography/Mass Spectrometry, Analytical Chemistry, vol.81, issue.9, pp.3285-3296, 2009.

U. Basu, J. Karges, F. Chotard, C. Balan, P. Le-gendre et al., Investigation of photo-activation on ruthenium(II)?arene complexes for the discovery of potential selective cytotoxic agents, Polyhedron, vol.172, pp.22-27, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02169667

A. K. Renfrew, J. Karges, R. Scopelliti, F. D. Bobbink, P. Nowak?sliwinska et al., Towards Light?Activated Ruthenium?Arene (RAPTA?Type) Prodrug Candidates, ChemBioChem, vol.20, issue.22, pp.2876-2882, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02140370

N. Alatrash, F. H. Issa, N. S. Bawazir, S. J. West, K. E. Van-manen-brush et al., Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium(ii) polypyridyl complex, Chemical Science, vol.11, issue.1, pp.264-275, 2020.

. Macdonnell, Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium(ii) polypyridyl complex, Chemi. Sci, vol.11, pp.264-275, 2020.

K. Mahmoudi, K. L. Garvey, A. Bouras, G. Cramer, H. Stepp et al., 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas, Journal of Neuro-Oncology, vol.141, issue.3, pp.595-607, 2019.

L. A. Pradelli, E. Villa, B. Zunino, S. Marchetti, and J. E. Ricci, Glucose metabolism is inhibited by caspases upon the induction of apoptosis, Cell Death & Disease, vol.5, issue.9, pp.e1406-e1406, 2014.

E. F. Mason and J. C. Rathmell, Cell metabolism: An essential link between cell growth and apoptosis, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1813, issue.4, pp.645-654, 2011.

J. Friedrich, C. Seidel, R. Ebner, and L. A. Kunz-schughart, Spheroid-based drug screen: considerations and practical approach, Nature Protocols, vol.4, issue.3, pp.309-324, 2009.

T. T. Goodman, C. P. Ng, and S. H. Pun, 3-D Tissue Culture Systems for the Evaluation and Optimization of Nanoparticle-Based Drug Carriers, Bioconjugate Chemistry, vol.19, issue.10, pp.1951-1959, 2008.

J. Liu, Y. Chen, G. Li, P. Zhang, C. Jin et al., Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents, Biomaterials, vol.56, pp.140-153, 2015.