Skip to Main content Skip to Navigation
Journal articles

Serum and brain natural copper stable isotopes in a mouse model of Alzheimer's disease

Abstract : Alzheimer’s disease is associated with the production of Cu rich aβ fibrils. Because monitoring the changes in Cu level of organs has been proposed to follow the evolution of the disease, we analyzed the copper isotopic composition of serum and brain of APPswe/PSEN1dE9 transgenic mice, a model of Alzheimer’s disease, and wild-type (WT) controls. Serum composition of 3, 6, 9 and 12-month-old mice, as well as the composition of 9 brains of 12-month-old mice are reported. In WT mice, brains were ~1‰ isotopically heavier than serum, and the Cu isotopic composition of the serum was isotopically different between males and females. We propose that this effect of sex on the Cu isotopic budget of the serum may be related to a difference of Cu speciation and relative abundance of Cu carriers. Brains of APPswe/PSEN1dE9 mice were slightly lighter than brains of WT mice, while not statistically significant. This trend may reflect an increase of Cu(I) associated with the formation of Aβ fibrils. The Cu isotopic composition of the brains and serum were correlated, implying copper transport between these two reservoirs, in particular a transfer of Cu(I) from the brain to the serum. Altogether, these data suggest that Cu stable isotopic composition of body fluid may have the potential to be used as detection tools for the formation of Aβ fibrils in the brain, but further work has to be done.
Document type :
Journal articles
Complete list of metadatas

Cited literature [58 references]  Display  Hide  Download

https://hal-insu.archives-ouvertes.fr/insu-02613087
Contributor : Eva Fareau <>
Submitted on : Tuesday, May 19, 2020 - 6:23:00 PM
Last modification on : Wednesday, October 21, 2020 - 3:06:06 AM

File

s41598-019-47790-5.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Frédéric Moynier, John Creech, Jessica Dallas, Marie Le Borgne. Serum and brain natural copper stable isotopes in a mouse model of Alzheimer's disease. Scientific Reports, Nature Publishing Group, 2019, 9, pp.:11894. ⟨10.1038/s41598-019-47790-5⟩. ⟨insu-02613087⟩

Share

Metrics

Record views

54

Files downloads

80