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Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

Abstract : The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.
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Yu-Chao Yuan, Raghu Kamaraj, Christian Bruneau, Thierry Labasque, Thierry Roisnel, et al.. Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives. Organic Letters, American Chemical Society, 2017, 19 (23), pp.6404-6407. ⟨10.1021/acs.orglett.7b03278⟩. ⟨insu-01639565⟩

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