Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

Abstract : The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.
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Article dans une revue
Organic Letters, American Chemical Society, 2017, 19 (23), pp.6404-6407. 〈10.1021/acs.orglett.7b03278〉
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https://hal-insu.archives-ouvertes.fr/insu-01639565
Contributeur : Isabelle Dubigeon <>
Soumis le : lundi 20 novembre 2017 - 14:38:50
Dernière modification le : samedi 24 mars 2018 - 01:48:18

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Yu-Chao Yuan, Raghu Kamaraj, Christian Bruneau, Thierry Labasque, Thierry Roisnel, et al.. Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives. Organic Letters, American Chemical Society, 2017, 19 (23), pp.6404-6407. 〈10.1021/acs.orglett.7b03278〉. 〈insu-01639565〉

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