A. Bahlmann, W. Brack, R. J. Schneider, and M. Krauss, Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal, Water Research, vol.57, pp.104-114, 2014.
DOI : 10.1016/j.watres.2014.03.022

D. R. Baker, L. Barron, and B. Kasprzyk-hordern, Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part A: Chemical analysis and drug use estimates, Science of The Total Environment, vol.487, pp.629-641, 2014.
DOI : 10.1016/j.scitotenv.2013.11.107

S. K. Behera, H. W. Kim, J. Oh, and H. Park, Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea, Science of The Total Environment, vol.409, issue.20, pp.4351-4360, 2011.
DOI : 10.1016/j.scitotenv.2011.07.015

J. Besse, C. Kausch-barreto, and J. Garric, Exposure Assessment of Pharmaceuticals and Their Metabolites in the Aquatic Environment: Application to the French Situation and Preliminary Prioritization, Human and Ecological Risk Assessment: An International Journal, vol.53, issue.4, pp.665-69510, 1080.
DOI : 10.1016/j.jhazmat.2005.03.001

URL : https://hal.archives-ouvertes.fr/hal-00454514

L. Bijlsma, E. Emke, F. Hernández, and P. De-voogt, Investigation of drugs of abuse and relevant metabolites in Dutch sewage water by liquid chromatography coupled to high resolution mass spectrometry, Chemosphere, vol.89, issue.11, pp.1399-1406, 2012.
DOI : 10.1016/j.chemosphere.2012.05.110

T. Brodin, S. Piovano, J. Fick, J. Klaminder, M. Heynen et al., Ecological effects of pharmaceuticals in aquatic systems--impacts through behavioural alterations, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.28, issue.1, 2014.
DOI : 10.1897/08-075.1

M. J. Bueno, M. J. Gomez, S. Herrera, M. D. Hernando, A. Agüera et al., Occurrence and persistence of organic emerging contaminants and priority pollutants in five sewage treatment plants of Spain: Two years pilot survey monitoring, Environmental Pollution, vol.164, pp.267-273, 2012.
DOI : 10.1016/j.envpol.2012.01.038

M. Carballa, F. Omil, and J. M. Lema, Comparison of predicted and measured concentrations of selected pharmaceuticals, fragrances and hormones in Spanish sewage, Chemosphere, vol.72, issue.8, 2008.
DOI : 10.1016/j.chemosphere.2008.04.034

S. Castiglioni, R. Bagnati, R. Fanelli, F. Pomati, D. Calamari et al., Removal of Pharmaceuticals in Sewage Treatment Plants in Italy, Environmental Science & Technology, vol.40, issue.1, pp.357-36310, 1021.
DOI : 10.1021/es050991m

S. Castiglioni, E. Zuccato, E. Crisci, C. Chiabrando, R. Fanelli et al., Identification and Measurement of Illicit Drugs and Their Metabolites in Urban Wastewater by Liquid Chromatography???Tandem Mass Spectrometry, Analytical Chemistry, vol.78, issue.24, pp.8421-842910, 1021.
DOI : 10.1021/ac061095b

H. Celle-jeanton, D. Schemberg, N. Mohammed, F. Huneau, G. Bertrand et al., Evaluation of pharmaceuticals in surface water: Reliability of PECs compared to MECs, Environment International, vol.73, pp.10-21, 2014.
DOI : 10.1016/j.envint.2014.06.015

URL : https://hal.archives-ouvertes.fr/hal-01136358

A. Chiffre, F. Degiorgi, A. Buleté, L. Spinner, and P. Badot, Occurrence of pharmaceuticals in WWTP effluents and their impact in a karstic rural catchment of Eastern France, Environmental Science and Pollution Research, vol.28, issue.474, pp.1-15, 2016.
DOI : 10.1002/jssc.200301727

N. Collado, S. Rodriguez-mozaz, M. Gros, A. Rubirola, D. Barceló et al., Pharmaceuticals occurrence in a WWTP with significant industrial contribution and its input into the river system, Environmental Pollution, vol.185, pp.202-212, 2014.
DOI : 10.1016/j.envpol.2013.10.040

S. Coutu, V. Wyrsch, H. K. Wynn, L. Rossi, and D. A. Barry, Temporal dynamics of antibiotics in wastewater treatment plant influent, Science of The Total Environment, vol.458, issue.460, pp.20-26, 2013.
DOI : 10.1016/j.scitotenv.2013.04.017

A. Dan, Y. Yang, D. Yu-nv, C. Chun-xing, W. Su-yu et al., Removal and factors influencing removal of sulfonamides and trimethoprim from domestic sewage in constructed wetlands, Bioresource Technology, vol.146, pp.363-370, 2013.
DOI : 10.1016/j.biortech.2013.07.050

D. Jongh, C. M. Kooij, P. J. De-voogt, P. Ter-laak, and T. L. , Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water, Science of The Total Environment, vol.427, issue.428, pp.427-428, 2012.
DOI : 10.1016/j.scitotenv.2012.04.010

T. Deblonde, C. Cossu-leguille, and P. Hartemann, Emerging pollutants in wastewater: A review of the literature, International Journal of Hygiene and Environmental Health, vol.214, issue.6, pp.442-448, 2010.
DOI : 10.1016/j.ijheh.2011.08.002

D. Fatta-kassinos, S. Meric, and A. Nikolaou, Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research, Analytical and Bioanalytical Chemistry, vol.39, issue.17, pp.251-275, 2011.
DOI : 10.1007/s00216-010-4300-9

G. Gatidou, J. Kinyua, A. L. Van-nuijs, E. Gracia-lor, S. Castiglioni et al., Drugs of abuse and alcohol consumption among different groups of population on the Greek Island of Lesvos through sewage-based epidemiology, Science of The Total Environment, vol.563, issue.564, pp.563-564, 2016.
DOI : 10.1016/j.scitotenv.2016.04.130

D. Gerrity, R. A. Trenholm, and S. A. Snyder, Temporal variability of pharmaceuticals and illicit drugs in wastewater and the effects of a major sporting event, Water Research, vol.45, issue.17, 2011.
DOI : 10.1016/j.watres.2011.07.020

O. Golovko, V. Kumar, G. Fedorova, T. Randak, and R. Grabic, Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant, Chemosphere, vol.111, pp.418-426, 2014.
DOI : 10.1016/j.chemosphere.2014.03.132

E. Gracia-lor, J. V. Sancho, R. Serrano, and F. Hernández, Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia, Chemosphere, vol.87, issue.5, pp.453-462, 2012.
DOI : 10.1016/j.chemosphere.2011.12.025

E. Gracia-lor, E. Zuccato, and S. Castiglioni, Refining correction factors for back-calculation of illicit drug use, Science of The Total Environment, vol.573, 2016.
DOI : 10.1016/j.scitotenv.2016.09.179

R. Gurke, M. Rößler, C. Marx, S. Diamond, S. Schubert et al., Occurrence and removal of frequently prescribed pharmaceuticals and corresponding metabolites in wastewater of a sewage treatment plant, Science of The Total Environment, vol.532, pp.762-770, 2015.
DOI : 10.1016/j.scitotenv.2015.06.067

W. Hall, J. Prichard, P. Kirkbride, R. Bruno, P. K. Thai et al., An analysis of ethical issues in using wastewater analysis to monitor illicit drug use, Addiction, vol.20, issue.10, pp.1767-1773, 2012.
DOI : 10.1111/j.1360-0443.2012.03887.x

R. Hirsch, T. Ternes, K. Haberer, and K. Kratz, Occurrence of antibiotics in the aquatic environment, Science of The Total Environment, vol.225, issue.1-2, pp.109-118, 1999.
DOI : 10.1016/S0048-9697(98)00337-4

M. Hörsing, A. Ledin, R. Grabic, J. Fick, M. Tysklind et al., Determination of sorption of seventy-five pharmaceuticals in sewage sludge, Water Research, vol.45, issue.15, pp.4470-4482, 2011.
DOI : 10.1016/j.watres.2011.05.033

A. Jelic, M. Gros, A. Ginebreda, R. Cespedes-sánchez, F. Ventura et al., Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment, Water Research, vol.45, issue.3, pp.1165-1176, 2011.
DOI : 10.1016/j.watres.2010.11.010

B. Kasprzyk-hordern, R. M. Dinsdale, and A. J. Guwy, Illicit drugs and pharmaceuticals in the environment ??? Forensic applications of environmental data. Part 1: Estimation of the usage of drugs in local communities, Environmental Pollution, vol.157, issue.6, pp.1773-1777, 2009.
DOI : 10.1016/j.envpol.2009.03.017

B. Kasprzyk-hordern, R. M. Dinsdale, and A. J. Guwy, The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK, Water Research, vol.42, issue.13, pp.3498-3518, 2008.
DOI : 10.1016/j.watres.2008.04.026

J. Klaminder, T. Brodin, A. Sundelin, N. J. Anderson, J. Fahlman et al., Long-Term Persistence of an Anxiolytic Drug (Oxazepam) in a Large Freshwater Lake, Environmental Science & Technology, vol.49, issue.17, pp.10406-10412, 2010.
DOI : 10.1021/acs.est.5b01968

C. I. Kosma, D. A. Lambropoulou, and T. A. Albanis, Investigation of PPCPs in wastewater treatment plants in Greece: Occurrence, removal and environmental risk assessment, Science of The Total Environment, vol.466, issue.467, pp.466-467, 2014.
DOI : 10.1016/j.scitotenv.2013.07.044

I. Krizman, I. Senta, M. Ahel, and S. Terzic, Wastewater-based assessment of regional and temporal consumption patterns of illicit drugs and therapeutic opioids in Croatia, Science of The Total Environment, vol.566, issue.567, pp.454-462, 2016.
DOI : 10.1016/j.scitotenv.2016.05.075

F. Y. Lai, S. Anuj, R. Bruno, S. Carter, C. Gartner et al., Systematic and Day-to-Day Effects of Chemical-Derived Population Estimates on Wastewater-Based Drug Epidemiology, Environmental Science & Technology, vol.49, issue.2, pp.999-100810, 1021.
DOI : 10.1021/es503474d

S. Lê, J. Josse, and F. Husson, FactoMineR: an R package for multivariate analysis, J. Stat. Softw, vol.25, 2008.

J. Lienert, K. Güdel, and B. I. Escher, Screening Method for Ecotoxicological Hazard Assessment of 42 Pharmaceuticals Considering Human Metabolism and Excretory Routes, Environmental Science & Technology, vol.41, issue.12, pp.4471-4478, 2007.
DOI : 10.1021/es0627693

R. H. Lindberg, M. Östman, U. Olofsson, R. Grabic, and J. Fick, Occurrence and behaviour of 105 active pharmaceutical ingredients in sewage waters of a municipal sewer collection system, Water Research, vol.58, pp.221-229, 2014.
DOI : 10.1016/j.watres.2014.03.076

R. Loos, B. M. Gawlik, G. Locoro, E. Rimaviciute, S. Contini et al., EU-wide survey of polar organic persistent pollutants in European river waters, Environmental Pollution, vol.157, issue.2, pp.561-568, 2009.
DOI : 10.1016/j.envpol.2008.09.020

B. Lopez, P. Ollivier, A. Togola, N. Baran, and J. Ghestem, Screening of French groundwater for regulated and emerging contaminants, Science of The Total Environment, vol.518, issue.519, pp.562-573, 2015.
DOI : 10.1016/j.scitotenv.2015.01.110

URL : https://hal.archives-ouvertes.fr/hal-01182211

T. Macku?ak, L. Biro?ová, I. Bodík, R. Grabic, A. Taká?ová et al., Zerovalent iron and iron(VI): Effective means for the removal of psychoactive pharmaceuticals and illicit drugs from wastewaters, Science of The Total Environment, vol.539, pp.420-426, 2016.
DOI : 10.1016/j.scitotenv.2015.08.138

R. Mailler, J. Gasperi, Y. Coquet, S. Deshayes, S. Zedek et al., Study of a large scale powdered activated carbon pilot: Removals of a wide range of emerging and priority micropollutants from wastewater treatment plant effluents, Water Research, vol.72, pp.315-330, 2015.
DOI : 10.1016/j.watres.2014.10.047

URL : https://hal.archives-ouvertes.fr/hal-01103115

S. Mompelat, L. Bot, B. Thomas, and O. , Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water, Environment International, vol.35, issue.5, 2009.
DOI : 10.1016/j.envint.2008.10.008

T. Nefau, S. Karolak, L. Castillo, V. Boireau, and Y. Levi, Presence of illicit drugs and metabolites in influents and effluents of 25 sewage water treatment plants and map of drug consumption in France, Science of The Total Environment, vol.461, issue.462, pp.461-462, 2013.
DOI : 10.1016/j.scitotenv.2013.05.038

C. Ort, A. L. Van-nuijs, J. Berset, L. Bijlsma, S. Castiglioni et al., Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis, Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis, pp.1338-1352
DOI : 10.1111/add.12570

M. Papageorgiou, C. Kosma, and D. Lambropoulou, Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece, Science of The Total Environment, vol.543, pp.547-569, 2016.
DOI : 10.1016/j.scitotenv.2015.11.047

A. M. Pereira, L. J. Silva, C. M. Lino, L. M. Meisel, and A. Pena, Assessing environmental risk of pharmaceuticals in Portugal: An approach for the selection of the Portuguese monitoring stations in line with Directive, Chemosphere, vol.39, issue.144, pp.2507-2515, 2013.

M. Petrovic, M. J. Alda, . De, S. Diaz-cruz, C. Postigo et al., Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.42, issue.4-5, pp.3979-40030105, 2009.
DOI : 10.1186/1476-069X-4-1

B. G. Plósz, H. Leknes, H. Liltved, and K. V. Thomas, Diurnal variations in the occurrence and the fate of hormones and antibiotics in activated sludge wastewater treatment in Oslo, Norway, Science of The Total Environment, vol.408, issue.8, 1915.
DOI : 10.1016/j.scitotenv.2010.01.042

C. Postigo, M. L. De-alda, and D. Barceló, Evaluation of drugs of abuse use and trends in a prison through wastewater analysis, Environment International, vol.37, issue.1, 2011.
DOI : 10.1016/j.envint.2010.06.012

C. Postigo, M. J. López-de-alda, and D. Barceló, Drugs of abuse and their metabolites in the Ebro River basin: Occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation, Environment International, vol.36, issue.1, pp.75-84, 2010.
DOI : 10.1016/j.envint.2009.10.004

J. Prichard, W. Hall, P. De-voogt, and E. Zuccato, Sewage epidemiology and illicit drug research: The development of ethical research guidelines, Science of The Total Environment, vol.472, 2014.
DOI : 10.1016/j.scitotenv.2013.11.039

M. Rattier, J. Reungoat, J. Keller, and W. Gernjak, Removal of micropollutants during tertiary wastewater treatment by biofiltration: Role of nitrifiers and removal mechanisms, Water Research, vol.54, 2014.
DOI : 10.1016/j.watres.2014.01.030

R. Rosal, A. Rodríguez, J. A. Perdigón-melón, A. Petre, E. García-calvo et al., Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation, Water Research, vol.44, issue.2, pp.578-588, 2010.
DOI : 10.1016/j.watres.2009.07.004

B. Subedi and K. Kannan, Mass Loading and Removal of Select Illicit Drugs in Two Wastewater Treatment Plants in New York State and Estimation of Illicit Drug Usage in Communities through Wastewater Analysis, Environmental Science & Technology, vol.48, issue.12, pp.6661-667010, 1021.
DOI : 10.1021/es501709a

Q. Sui, J. Huang, S. Deng, W. Chen, and G. Yu, Seasonal Variation in the Occurrence and Removal of Pharmaceuticals and Personal Care Products in Different Biological Wastewater Treatment Processes, Environmental Science & Technology, vol.45, issue.8, pp.3341-334810, 1021.
DOI : 10.1021/es200248d

S. Terzic, I. Senta, and M. Ahel, Illicit drugs in wastewater of the city of Zagreb (Croatia) ??? Estimation of drug abuse in a transition country, Environmental Pollution, vol.158, issue.8, pp.2686-2693, 2010.
DOI : 10.1016/j.envpol.2010.04.020

T. Thiebault, M. Boussafir, R. Guégan, L. Milbeau, C. et al., Clayey?sand filter for the removal of pharmaceuticals from wastewater effluent: percolation experiments Occurrence and removal efficiency of pharmaceuticals in an urban wastewater treatment plant: mass balance and consumption assessment, Environ. Sci. Water Res. Technol. Submitt. J. Environ. Chem. Eng, vol.2, pp.529-538, 2016.

K. V. Thomas, L. Bijlsma, S. Castiglioni, A. Covaci, E. Emke et al., Comparing illicit drug use in 19 European cities through sewage analysis, Science of The Total Environment, vol.432, pp.432-439, 2012.
DOI : 10.1016/j.scitotenv.2012.06.069

URL : http://hdl.handle.net/11245/1.372639

A. L. Van-nuijs, J. Mougel, I. Tarcomnicu, L. Bervoets, R. Blust et al., Sewage epidemiology ??? A real-time approach to estimate the consumption of illicit drugs in Brussels, Belgium, Environment International, vol.37, issue.3, pp.612-621, 2011.
DOI : 10.1016/j.envint.2010.12.006

L. Vergeynst, A. Haeck, P. De-wispelaere, H. Van-langenhove, and K. Demeestere, Multiresidue analysis of pharmaceuticals in wastewater by liquid chromatography?magnetic sector mass spectrometry: Method quality assessment and application in a Belgian case study, Emerg. Pollut, vol.119, pp.2-8, 2015.

P. Verlicchi, A. Galletti, M. Petrovic, D. Barceló, A. Aukidy et al., Removal of selected pharmaceuticals from domestic wastewater in an activated sludge system followed by a horizontal subsurface flow bed ??? Analysis of their respective contributions, Science of The Total Environment, vol.454, issue.455, pp.454-455, 2013.
DOI : 10.1016/j.scitotenv.2013.03.044

P. Verlicchi, A. Aukidy, M. Zambello, and E. , Occurrence of pharmaceutical compounds in urban wastewater: Removal, mass load and environmental risk after a secondary treatment???A review, Science of The Total Environment, vol.429, pp.123-155, 2012.
DOI : 10.1016/j.scitotenv.2012.04.028

E. Vuori, M. Happonen, M. Gergov, T. Nenonen, A. Järvinen et al., Wastewater analysis reveals regional variability in exposure to abused drugs and opioids in Finland, Science of The Total Environment, vol.487, pp.688-695, 2014.
DOI : 10.1016/j.scitotenv.2013.11.010

A. Wick, G. Fink, A. Joss, H. Siegrist, and T. A. Ternes, Fate of beta blockers and psycho-active drugs in conventional wastewater treatment, Water Research, vol.43, issue.4, pp.1060-1074, 2009.
DOI : 10.1016/j.watres.2008.11.031

Q. Yan, X. Gao, L. Huang, X. Gan, Y. Zhang et al., Occurrence and fate of pharmaceutically active compounds in the largest municipal wastewater treatment plant in Southwest China: Mass balance analysis and consumption back-calculated model, Chemosphere, vol.99, pp.160-170, 2014.
DOI : 10.1016/j.chemosphere.2013.10.062

E. Zuccato, C. Chiabrando, S. Castiglioni, R. Bagnati, and R. Fanelli, Estimating Community Drug Abuse by Wastewater Analysis, Environmental Health Perspectives, vol.116, issue.8, pp.1027-1032, 2008.
DOI : 10.1289/ehp.11022

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516581