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SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION ON ZINC DOPED HYDROXYAPATITE IN COLLAGEN MATRIX

Abstract : The goal of this study was to obtain at low temperature a functional nano-composite with characteristics similar to the natural bone by using a cost effective method. The structure and morphology of collagen coated zinc doped hydroxyapatite bio-composites (Zn:HAp-CBc) were examined by X-Ray diffraction (XRD) and Scanning Electron Microscopy (SEM). XRD analysis revealed that the unique hexagonal Ca 10 (PO 4) 6 (OH) 2 in P 63m space group was observed in the obtained nanocomposites Zn:HAp-CBc. The cytotoxicity of the Zn:HAp-CBc was studied on HeLa cell lines. Cell cycle distribution after treatment was examined by flow cytometry analysis. Our preliminary in vitro studies revealed that the obtained composites based on Zn doped HAp embedded in collagen matrix have excellent biocompatibility and support their further characterization by in vivo approaches and development as a biomaterial used in bone regeneration.
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C.L. Popa, C.M. Bartha, M Albu, Régis Guégan, Mikael Motelica-Heino, et al.. SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION ON ZINC DOPED HYDROXYAPATITE IN COLLAGEN MATRIX. Digest Journal of Nanomaterials and Biostructures , Forum of Chalcogeniders, 2015, 10 (2), pp.681-691. ⟨insu-01363294⟩

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