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Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response

Abstract : An alternative and simple coprecipitation method was developed to obtain carbon nanotube-hydroxyapatite (CNTs:HAp) based nanocomposites. The incorporation of CNTs (in a concentration of 5% and 10% of total weight of the nanocomposite) and their impact on both structural and biological properties were studied by using a set of standard complementary biological, microscopic, and spectroscopic techniques. The characteristic peaks of carbon structure in CNTs were not observed in the CNTs-HAp composites by X-ray diffraction analysis. Moreover, FTIR and Raman spectroscopies confirmed the presence of HAp as the main phase of the synthesized CNTs:HAp nanocomposites. The addition of CNTs considerably affected the nanocomposite morphology by increasing the average crystallite size from 18.7 nm (for raw HAp) to 28.6 nm (for CNTs:HAp-10), confirming their proper incorporation. The biocompatibility evaluation of CNTs:HAp-5 and CNTs:HAp-10 nanocomposites included the assessment of several parameters, such as cell viability, antioxidant response, and lipid peroxidation, on human G-292 osteoblast cell line. Our findings revealed good biocompatibility properties for CNTs:HAp nanocomposites prepared by the coprecipitation method supporting their potential uses in orthopedics and prosthetics.
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Sabrina Constanda, Miruna Silvia Stan, Carmen Steluta Ciobanu, Mikael Motelica-Heino, Régis Guégan, et al.. Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response. Journal of Nanomaterials, Hindawi Publishing Corporation, 2016, 10 p. ⟨10.1155/2016/3941501⟩. ⟨insu-01294590⟩

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