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Hepatitis C virus drives increased type I interferon-associated impairments associated with fibrosis severity in antiretroviral treatment-treated HIV-1-hepatitis C virus-coinfected individuals

Abstract : On behalf of the HepACT-VIH study group - Viral coinfections might contribute to the increased immune activation and inflammation that persist in antiretroviral treatment (ART)-treated HIV-1 patients. We investigated whether the hepatitis C virus (HCV) coinfection contributes to such alterations by impairing the plasmacytoid dendritic cell (pDC) IFNa/TLR7 pathway in a highly homogeneous group of ART-treated HIV-1-HCV-coinfected patients.
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https://hal.sorbonne-universite.fr/hal-02548458
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Morgane Griesbeck, Marc-Antoine Valantin, Karine Lacombe, Assia Samri-Hassimi, Julie Bottero, et al.. Hepatitis C virus drives increased type I interferon-associated impairments associated with fibrosis severity in antiretroviral treatment-treated HIV-1-hepatitis C virus-coinfected individuals. HIV/AIDS surveillance report (Atlanta, Ga.), 2017, ⟨10.1097/QAD.0000000000001455⟩. ⟨hal-02548458⟩

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