Skip to Main content Skip to Navigation
Journal articles

Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans

Abstract : Neural stem cells (NSCs) continuously produce new neurons within the adult mammalian hippocampus. NSCs are typically quiescent but activated to self-renew or differentiate into neural progenitor cells. The molecular mechanisms of NSC activation remain poorly understood. Here, we show that adult hippocampal NSCs express vascular endothelial growth factor receptor (VEGFR) 3 and its ligand VEGF-C, which activates quiescent NSCs to enter the cell cycle and generate progenitor cells. Hippocampal NSC activation and neurogenesis are impaired by conditional deletion of Vegfr3 in NSCs. Functionally, this is associated with compromised NSC activation in response to VEGF-C and physical activity. In NSCs derived from human embryonic stem cells (hESCs), VEGF-C/VEGFR3 mediates intracellular activation of AKT and ERK pathways that control cell fate and proliferation. These findings identify VEGF-C/VEGFR3 signaling as a specific regulator of NSC activation and neurogenesis in mammals.
Document type :
Journal articles
Complete list of metadatas

Cited literature [63 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-01213839
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Friday, October 9, 2015 - 10:42:44 AM
Last modification on : Thursday, December 10, 2020 - 3:43:55 AM
Long-term archiving on: : Sunday, January 10, 2016 - 10:17:59 AM

File

1-s2.0-S2211124715000741-main....
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Jinah Han, Charles-Félix Calvo, Tae hyuk Kang, Kasey l. Baker, June-Hee Park, et al.. Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans. Cell Reports, Elsevier Inc, 2015, 10 (7), pp.1158-1172. ⟨10.1016/j.celrep.2015.01.049⟩. ⟨hal-01213839⟩

Share

Metrics

Record views

1280

Files downloads

474