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Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation

Résumé : Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell activities allowed to quantify the impact of the uptaken NPs on cell proliferation and after washout of the NPs from the cell culture medium. The results show more toxic effects of the CFO NPs on cancer than on non-cancer cell lines. The notion of NPs biocompatibility must be related to a maximum concentration value of the NPs acceptable for a given cell type. Furthermore, the cytotoxicity effects of NPs should be studied not only during their direct exposure to cells but also after their washout from the culture medium
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https://hal.archives-ouvertes.fr/hal-03444199
Contributor : Vladimir Lysenko Connect in order to contact the contributor
Submitted on : Tuesday, November 23, 2021 - 4:25:47 PM
Last modification on : Tuesday, January 11, 2022 - 3:06:42 AM

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2021_Nanomaterials_Alain.pdf
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Alain Géloën, Gauhar Mussabek, Alexander Kharin, Tetiana Serdiuk, Sergei Alekseev, et al.. Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation. Nanomaterials, MDPI, 2021, 11 (12), pp.3168. ⟨10.3390/nano11123168⟩. ⟨hal-03444199⟩

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