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Theses

Link prediction in bipartite multi-layer networks, with an application to drug-target interaction prediction

Abstract : Many aspects from real life with bi-relational structure can be modeled as bipartite networks. This modeling allows the use of some standard solutions for prediction and/or recommendation of new relations between these objects in such networks. Known as the link prediction task, it is a widely studied problem in network science for single graphs, networks assuming one type of interaction between vertices. For multi-layer networks, allowing more than one type of edges between vertices, the problem is not yet fully solved.The motivation of this thesis comes from the importance of an application task, drug-target interaction prediction. Searching valid drug candidates for a given biological target is an essential part of modern drug development. In this thesis, the problem is modeled as link prediction in a bipartite multi-layer network. Modeling the problem in this setting helps to aggregate different sources of information into one single structure and as a result to improve the quality of link prediction.The thesis mostly focuses on the problem of link prediction in bipartite multi-layer networks and makes two main contributions on this topic.The first contribution provides a solution for solving link prediction in the given setting without limiting the number and type of networks, the main constrains of the state of the art methods. Modeling random walk in the fashion of PageRank, the algorithm that we developed is able to predict new interactions in the network constructed from different sources of information. The second contribution, which solves link prediction using community information, is less straight-forward and more dependent on fixing the parameters, but provides better results. Adopting existing community measures for link prediction to the case of bipartite multi-layer networks and proposing alternative ways for exploiting communities, the method offers better performance and efficiency. Additional evaluation on the data of a different origin than drug-target interactions demonstrate the genericness of proposed approach.In addition to the developed approaches, we propose a framework for validation of predicted interactions founded on an external resource. Based on a collection of biomedical concepts used as a knowledge source, the framework is able to perform validation of drug-target pairs using proposed confidence scores. An evaluation of predicted interactions performed on unseen data shows effectiveness of this framework.At the end, a problem of identification and characterization of promiscuous compounds existing in the drug development process is discussed. The problem is solved as a machine learning classification task. The contribution includes graph mining and sampling approaches. In addition, a graphical interface was developed to provide feedback of the result for experts.
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https://hal.archives-ouvertes.fr/tel-02983246
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Submitted on : Friday, December 11, 2020 - 10:38:46 AM
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  • HAL Id : tel-02983246, version 2

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Maksim Koptelov. Link prediction in bipartite multi-layer networks, with an application to drug-target interaction prediction. Automatic Control Engineering. Normandie Université, 2020. English. ⟨NNT : 2020NORMC211⟩. ⟨tel-02983246v2⟩

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