Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary

Marine Huin (1, 2) , Jerome Lorenzini (1, 2) , Flavie Arbion (1) , Xavier Carcopino (3, 4) , Cyril Touboul (5) , Yohann Dabi (5) , Yohan Kerbage (6, 7) , Hélène Costaz (8) , Lise Lecointre (9) , Vincent Lavoué (10, 11) , Pierre-Adrien Bolze (12, 13) , Cyrille Huchon (14, 15, 16) , Alexandre Bricou (17) , Geoffroy Canlorbe (18) , Camille Mimoun (19) , Sofiane Bendifallah (20) , Tristan Gauthier (21) , Gilles Body (1, 2) , Lobna Ouldamer (1, 2)

1 CHU Trousseau [Tours]
2 N2Cox - Niche, Nutrition, Cancer et métabolisme oxydatif
3 Hôpital Nord [CHU - APHM]
4 AMU - Aix Marseille Université
5 CHIC - Centre Hospitalier Intercommunal de Créteil
6 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
7 Hôpital Jeanne de Flandre [Lille]
8 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
9 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
10 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
11 OSS - Oncogenesis, Stress, Signaling
12 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
13 UCBL - Université Claude Bernard Lyon 1
14 RISCQ - Risques cliniques et sécurité en santé des femmes et en santé périnatale
15 CHI Poissy-Saint-Germain
16 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
17 Hôpital Jean Verdier [AP-HP]
18 CHU Pitié-Salpêtrière [AP-HP]
19 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
20 CHU Tenon [AP-HP]
21 CHU Limoges

Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/ expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. Results: A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic /para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Conclusions: Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course.

Mots clés: expansile mucinous carcinomas; mucinous ovarian carcinoma; lymphadenectomy; prognosis

Domaines: Cancer

Marine Huin, Jerome Lorenzini, Flavie Arbion, Xavier Carcopino, Cyril Touboul, et al.. Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary. Journal of Clinical Medicine, 2022, 11 (20), pp.6120. ⟨10.3390/jcm11206120⟩. ⟨hal-03886170⟩