Aspects cliniques et neurofonctionnels impliqués dans le cours évolutif de la dépression : l’expérience d’une cohorte en soins courants

Abstract : The aim of this work is to study anxiety and apathy in treatment resistant depression. These clinical factors and its imaging correlates will be tested in prediction of outcome in a 6-months follow-up. Original data were retrieved in LONGIDEP cohort. This is a prospective study conducted in routine care. Patients suffering from a mood depressive episode benefited from a clinical, neuropsychological and brain imaging. They were assessed once again at 6 months. Our study has shown that 1) apathy in depression is associated with specific clinical and pathophysiological patterns, 2) categorical and dimensional approach of anxiety in treatment resistant depression are not convergent. This latter population exhibited higher brain perfusion of centro-medial amygdala, 3) trait anxiety, cognitive patterns of visuospatial memory were predictive of pejorative outcome. Structural abnormalities in key regions involved in emotion regulation were associated with pejorative outcome of depression. Only anxiety was involved in outcome of depression. The link between anxiety and motivation should be studied in further works.
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Jean-Marie Batail. Aspects cliniques et neurofonctionnels impliqués dans le cours évolutif de la dépression : l’expérience d’une cohorte en soins courants. Médecine humaine et pathologie. Université Rennes 1, 2018. Français. ⟨NNT : 2018REN1B055⟩. ⟨tel-02414268⟩

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